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| # | Pitcher | Team | Matchup | ERA | WHIP | K/9 |
|---|---|---|---|---|---|---|
| 1 | Logan Allen | CLE | vs PIT | 0.00 | 1.50 | 15.8 |
| 2 | Randy Dobnak | KC | vs SD | 1.86 | 1.34 | 3.7 |
| 3 | Patrick Sandoval | BOS | vs TB | 2.08 | 1.38 | 10.4 |
| 4 | Owen Murphy | ATL | vs TEX | 2.25 | 0.25 | 9.0 |
| 5 | Max Meyer | MIA | @ MIL | 2.58 | 1.11 | 9.7 |
| 6 | Tarik Skubal | DET | @ LAA | 3.09 | 0.95 | 10.6 |
| 7 | Shane Drohan | MIL | vs MIA | 3.09 | 1.20 | 8.6 |
| 8 | Davis Martin | CWS | @ TOR | 3.41 | 1.29 | 8.3 |
| 9 | Jesús Luzardo | PHI | vs NYM | 3.51 | 1.22 | 11.1 |
| 10 | Taj Bradley | MIN | @ CHC | 3.59 | 1.22 | 10.3 |
| 11 | J.T. Ginn | ATH | vs WSH | 3.67 | 1.25 | 8.1 |
| 12 | Gavin Williams | CLE | vs PIT | 3.81 | 1.15 | 10.6 |
| 13 | Logan Webb | SF | @ SEA | 3.86 | 1.16 | 7.2 |
| 14 | Ryan Weathers | NYY | vs LAD | 4.15 | 1.24 | 10.1 |
| 15 | Bryan Woo | SEA | vs SF | 4.23 | 1.07 | 8.8 |
| 16 | Jared Jones | PIT | @ CLE | 4.37 | 1.14 | 10.0 |
| 17 | Trevor Rogers | BAL | @ HOU | 4.48 | 1.31 | 6.9 |
| 18 | Matthew Boyd | CHC | vs MIN | 4.50 | 1.28 | 9.2 |
| 19 | Spencer Arrighetti | HOU | vs BAL | 4.50 | 1.33 | 8.9 |
| 20 | Dustin May | STL | @ ARI | 4.55 | 1.26 | 8.6 |