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| # | Pitcher | Team | Matchup | ERA | WHIP | K/9 |
|---|---|---|---|---|---|---|
| 1 | Parker Messick | CLE | vs DET | 2.46 | 1.02 | 9.0 |
| 2 | Tyler Glasnow | LAD | vs WSH | 2.79 | 0.81 | 10.8 |
| 3 | Sonny Gray | BOS | @ BAL | 2.82 | 1.18 | 8.0 |
| 4 | Zac Thornton | NYM | vs SF | 2.93 | 1.16 | 6.6 |
| 5 | Drew Rasmussen | TB | @ TEX | 2.95 | 0.93 | 9.2 |
| 6 | Mason Adams | COL | vs STL | 3.00 | 1.44 | 10.0 |
| 7 | Martín Pérez | ATL | @ PHI | 3.05 | 1.21 | 6.8 |
| 8 | Cade Cavalli | WSH | @ LAD | 3.12 | 1.20 | 10.4 |
| 9 | Robbie Ray | SD | vs NYY | 3.14 | 1.30 | 7.6 |
| 10 | Carlos Rodón | NYY | @ SD | 3.20 | 1.19 | 9.6 |
| 11 | Zack Wheeler | PHI | vs ATL | 3.31 | 1.09 | 10.6 |
| 12 | Brandon Pfaadt | ARI | @ HOU | 3.49 | 1.14 | 5.9 |
| 13 | Braxton Ashcraft | PIT | vs LAA | 3.59 | 1.08 | 9.2 |
| 14 | Anthony Molina | SF | @ NYM | 3.77 | 1.05 | 5.7 |
| 15 | Taj Bradley | MIN | @ CWS | 3.85 | 1.26 | 10.4 |
| 16 | Ryan Gusto | MIA | vs CHC | 3.86 | 1.33 | 7.6 |
| 17 | Jacob deGrom | TEX | vs TB | 4.00 | 1.13 | 10.9 |
| 18 | George Kirby | SEA | vs ATH | 4.19 | 1.35 | 7.6 |
| 19 | Anthony Kay | CWS | vs MIN | 4.28 | 1.35 | 7.4 |
| 20 | Framber Valdez | DET | @ CLE | 4.36 | 1.40 | 6.9 |